Report of the workflow results

Author

Ellis Franklin

Published

2024-04-26

1 The results as an interactive table

2 The results as sensitivity plots

Figure 1: Sensitivity plot of clusters summarised by BMD first quartile


Figure 2: Sensitivity plot of clusters summarised by BMD median with the interquartile range as an interval

3 The top 10 most sensitive clusters

Cluster 50 - 9 transcripts (~ 25% < 1.95 μg/L)

Driver GO terms :

KEGG pathways : Retinol metabolism

Wikipathways :

Figure 3: DR curves for the 1st cluster
Figure 4: BMDplot for the 1st cluster
id BMD.zSD TF trend
cyp27c1 7.3 FALSE inc
cyp3c1_1.2 42.0 FALSE inc
cyp3c3_2.1 1.2 FALSE U
lrata 37.8 FALSE inc
lratb.2 1.9 FALSE inc
ugt1b1_1.2 3.8 FALSE dec
ugt2a7_2.2 2.5 FALSE dec
ugt2a7_3.1 1.7 FALSE dec
zgc:77938 2.9 FALSE dec
Figure 5: Table of the 1st cluster content


Cluster 66 - 4 transcripts (~ 25% < 2.06 μg/L)

Driver GO terms :

KEGG pathways :

Wikipathways :

Figure 6: DR curves for the 2nd cluster
Figure 7: BMDplot for the 2nd cluster
id BMD.zSD TF trend
atg3 2.2 FALSE U
pi4kaa 42.3 FALSE dec
pik3c3_1.2 3.9 FALSE inc
rab5ab 1.7 FALSE dec
Figure 8: Table of the 2nd cluster content


Cluster 49 - 4 transcripts (~ 25% < 2.58 μg/L)

Driver GO terms :

KEGG pathways :

Wikipathways :

Figure 9: DR curves for the 3rd cluster
Figure 10: BMDplot for the 3rd cluster
id BMD.zSD TF trend
glo1 45.4 FALSE inc
mccc2 3.0 FALSE U
sdsl 1.2 FALSE dec
tdh2 36.5 FALSE dec
Figure 11: Table of the 3rd cluster content


Cluster 17 - 32 transcripts (~ 25% < 2.64 μg/L)

Driver GO terms : lipid biosynthetic process

KEGG pathways : Steroid biosynthesis

Wikipathways : Cholesterol biosynthesis

Figure 12: DR curves for the 4th cluster
Figure 13: BMDplot for the 4th cluster
id BMD.zSD TF trend
acsl1b 2.18 FALSE dec
alox12 3.38 FALSE dec
cers5 2.59 FALSE dec
crppa 18.97 FALSE inc
cyp17a1 2.73 FALSE dec
cyp27b1 3.01 FALSE dec
dhcr7 2.41 FALSE dec
ERG28 41.26 FALSE dec
fdft1_1.2 1.49 FALSE dec
fitm1l 27.73 FALSE inc
fnta_1.2 1.88 FALSE dec
fnta_1.3 30.02 FALSE inc
gpam 30.83 FALSE dec
hmgcs1_1.2 2.98 FALSE dec
impad1 2.66 FALSE dec
insig2 36.86 FALSE dec
lss 0.49 FALSE U
nus1 28.81 FALSE dec
pisd_2.1 57.14 FALSE dec
ptdss2_1.2 22.71 FALSE dec
PYURF_1.1 7.37 FALSE inc
sc5d 2.28 FALSE dec
scap 37.09 FALSE dec
sccpdha.1 1.98 FALSE dec
scd 23.97 FALSE inc
selenoi 3.77 FALSE dec
si:dkey-205h13.1_1.2 3.42 FALSE inc
si:dkey-91i10.3 3.26 FALSE dec
st6galnac4 23.11 FALSE dec
tamm41 34.60 FALSE inc
ugt8_2.1 4.12 FALSE dec
zgc:77375 34.02 FALSE dec
Figure 14: Table of the 4th cluster content


Cluster 52 - 34 transcripts (~ 25% < 2.98 μg/L)

Driver GO terms : cellular lipid metabolic process

KEGG pathways :

Wikipathways :

Figure 15: DR curves for the 5th cluster
Figure 16: BMDplot for the 5th cluster
id BMD.zSD TF trend
abcd1_1.2 4.68 FALSE dec
acox3 3.06 FALSE dec
acsl1b 2.18 FALSE dec
alox12 3.38 FALSE dec
cers5 2.59 FALSE dec
cpt1aa_1.2 2.96 FALSE dec
crppa 18.97 FALSE inc
enpp7.1_3.1 0.84 FALSE U
fa2h_1.3 1.67 FALSE dec
fitm1l 27.73 FALSE inc
gba2_1.2 1.39 FALSE dec
gpam 30.83 FALSE dec
hexb_1.3 39.70 FALSE dec
impad1 2.66 FALSE dec
mboat2a 24.39 FALSE dec
mtmr3_2.2 17.77 FALSE dec
mtmr7a_2.1 1.61 FALSE inc
nus1 28.81 FALSE dec
pisd_2.1 57.14 FALSE dec
plcg2_1.2 4.02 FALSE dec
proca1 3.66 FALSE inc
ptdss2_1.2 22.71 FALSE dec
PYURF_1.1 7.37 FALSE inc
sccpdha.1 1.98 FALSE dec
scd 23.97 FALSE inc
selenoi 3.77 FALSE dec
si:dkey-205h13.1_1.2 3.42 FALSE inc
smpd3 49.35 FALSE dec
srd5a3 25.25 FALSE inc
st6galnac4 23.11 FALSE dec
tamm41 34.60 FALSE inc
taz_1.4 35.85 FALSE inc
ugt8_2.1 4.12 FALSE dec
zgc:77375 34.02 FALSE dec
Figure 17: Table of the 5th cluster content


Cluster 48 - 4 transcripts (~ 25% < 3.01 μg/L)

Driver GO terms :

KEGG pathways :

Wikipathways :

Figure 18: DR curves for the 6th cluster
Figure 19: BMDplot for the 6th cluster
id BMD.zSD TF trend
cbfa2t3_1.2 2.5 FALSE bell
ldb1b_1.2 31.6 TRUE dec
lmo1_1.1 3.2 TRUE inc
tcf3a_1.2 35.7 TRUE dec
Figure 20: Table of the 6th cluster content


Cluster 68 - 29 transcripts (~ 25% < 3.03 μg/L)

Driver GO terms : muscle contraction

KEGG pathways : Motor proteins

Wikipathways :

Figure 21: DR curves for the 7th cluster
Figure 22: BMDplot for the 7th cluster
id BMD.zSD TF trend
atp2a1_1.1 42.98 FALSE inc
BX936363.1 33.56 FALSE dec
cald1a 4.63 FALSE dec
cx39.9 27.78 FALSE inc
dctn1a_1.2 35.74 FALSE dec
dctn4_1.3 4.08 FALSE bell
dynll2b 3.69 FALSE inc
erp44 3.03 FALSE dec
htr1d 2.67 FALSE inc
kif1b_1.1 5.11 FALSE dec
kifc1_1.2 26.20 FALSE inc
kifc3_1.5 45.08 FALSE dec
myhz1.1_2.1 2.79 FALSE inc
myhz1.2_1.2 1.92 FALSE inc
myhz1.3 4.89 FALSE inc
mylpfa_1.2 4.62 FALSE inc
myo1b_1.3 2.90 FALSE dec
MYO1D 4.14 FALSE dec
rock2a_1.2 3.57 FALSE U
scn4ba 34.66 FALSE dec
tnnc2 6.22 FALSE inc
tnni2a.4_1.2 24.82 FALSE inc
tnni4b.2 29.69 FALSE inc
tnnt1_1.2 0.16 FALSE bell
tnnt1_1.3 51.02 FALSE inc
tnnt3b_1.4 3.91 FALSE inc
tnnt3b_1.5 1.94 FALSE inc
tpma_1.3 49.56 FALSE inc
tubb4b_1.2 2.47 FALSE dec
Figure 23: Table of the 7th cluster content


Cluster 56 - 29 transcripts (~ 25% < 3.08 μg/L)

Driver GO terms : carbohydrate metabolic process

KEGG pathways : N-Glycan biosynthesis, Various types of N-glycan biosynthesis

Wikipathways :

Figure 24: DR curves for the 8th cluster
Figure 25: BMDplot for the 8th cluster
id BMD.zSD TF trend
agla_1.1 3.0 FALSE dec
b4galt6 38.5 FALSE dec
CABZ01079192.1 1.7 FALSE dec
chia.1 0.3 FALSE U
CR759923.1_1.4 2.2 FALSE inc
CR774178.2 5.1 FALSE dec
eno1a_1.2 5.3 FALSE inc
ganab 34.4 FALSE dec
GANAB_1.2 2.6 FALSE dec
gcgra_2.1 3.5 FALSE dec
hexa_1.1 30.8 FALSE dec
hexb_1.3 39.7 FALSE dec
hkdc1_2.1 3.1 FALSE dec
insrb 35.5 FALSE dec
kctd10 4.7 FALSE U
lancl1 1.9 FALSE inc
man1a1 36.4 FALSE dec
man1b1b 36.7 FALSE dec
MAN1C1_1.2 29.0 FALSE dec
man2a1 3.1 FALSE dec
mgat5 35.6 FALSE dec
myorg 3.3 FALSE dec
pdk1 32.3 FALSE dec
pgk1 36.4 FALSE inc
phkb_1.4 4.6 FALSE inc
phkg1b_1.2 42.1 FALSE inc
phkg2 4.6 FALSE U
srd5a3 25.2 FALSE inc
st6galnac4 23.1 FALSE dec
Figure 26: Table of the 8th cluster content


Cluster 64 - 36 transcripts (~ 25% < 3.23 μg/L)

Driver GO terms : protein glycosylation

KEGG pathways : N-Glycan biosynthesis, Protein processing in endoplasmic reticulum, Various types of N-glycan biosynthesis

Wikipathways :

Figure 27: DR curves for the 9th cluster
Figure 28: BMDplot for the 9th cluster
id BMD.zSD TF trend
alg11_1.2 23.4 FALSE dec
atf6 30.3 TRUE dec
calr3b 4.1 FALSE dec
canx 4.1 FALSE dec
crppa 19.0 FALSE inc
dnajb11 2.9 FALSE dec
dnajc1 33.8 TRUE inc
dnajc5aa 39.5 FALSE dec
eif2s1b 34.6 FALSE inc
ext1c_1.1 1.5 FALSE inc
ganab 34.4 FALSE dec
GANAB_1.2 2.6 FALSE dec
hexb_1.3 39.7 FALSE dec
hsp70l 68.6 FALSE inc
hspa1b 20.5 TRUE inc
march6_1.2 39.1 FALSE dec
mgat5 35.6 FALSE dec
mlec 2.9 FALSE dec
ogt.1_2.1 2.9 FALSE inc
pdia3_1.2 3.0 FALSE dec
pdia6 5.5 FALSE dec
pomgnt1_1.2 33.9 FALSE inc
pomgnt1_2.1 36.1 FALSE inc
pomt2 29.4 FALSE inc
rnf185_1.2 28.7 FALSE inc
RNF5 31.9 FALSE dec
rpn1_1.2 3.3 FALSE dec
rpn2_1.1 4.0 FALSE dec
sec61b_1.2 3.2 FALSE dec
selenos 3.2 FALSE U
srd5a3 25.2 FALSE inc
ssr2_1.2 2.8 FALSE dec
st3gal7 2.8 FALSE dec
st6galnac4 23.1 FALSE dec
stt3b 3.3 FALSE dec
xbp1_1.2 48.4 TRUE inc
Figure 29: Table of the 9th cluster content


Cluster 29 - 30 transcripts (~ 25% < 3.31 μg/L)

Driver GO terms : RNA splicing, via transesterification reactions

KEGG pathways : Spliceosome

Wikipathways :

Figure 30: DR curves for the 10th cluster
Figure 31: BMDplot for the 10th cluster
id BMD.zSD TF trend
gemin2 32.3 FALSE inc
gemin8_2.1 42.5 FALSE dec
hnrnpa1b_1.2 2.2 FALSE inc
hnrnpk_1.3 59.0 FALSE dec
hnrnpm_1.3 2.0 FALSE bell
hnrnpm_1.4 33.9 FALSE dec
hnrnpua 45.0 FALSE dec
hsp70l 68.6 FALSE inc
hspa1b 20.5 TRUE inc
LSM2_1.4 3.2 FALSE dec
lsm5_1.2 4.4 FALSE inc
pcbp4_1.1 2.5 FALSE dec
puf60a_1.3 3.5 TRUE inc
rbm15_2.1 35.7 TRUE dec
rbm4.2 1.8 FALSE bell
rbm4.3 24.1 FALSE dec
rbm5_1.2 36.6 FALSE dec
rp9_1.3 3.2 FALSE inc
sf1_1.2 41.2 FALSE dec
sf3b6 32.7 FALSE inc
snrnp25 29.2 FALSE inc
snrnp27 42.6 FALSE inc
snrpd2 57.0 FALSE inc
snrpg 40.8 FALSE inc
snu13b 40.3 FALSE inc
srsf5b_1.1 3.2 FALSE bell
taf15_1.1 1.4 FALSE dec
thoc1 32.0 FALSE inc
wbp11_1.1 33.1 FALSE dec
zgc:55733_1.2 33.6 TRUE inc
Figure 32: Table of the 10th cluster content